Purpose: The purpose of the research was to evaluate the influence of supply chain uncertainty on the Malaysian companies' agility performance. In addition, the mediation of supply chain integration was also tested. Method: The method employed in this research was quantitative where a survey was employed to collect primary data from the employees. The sample size in this study was 310 participants that were evaluated using SEM modelling in SmartPLS. Findings: It was found from the analysis that the company and environment uncertainty affected the agility performance of Malaysian companies significantly. In the context of mediation, supply chain integration was found to be mediating the relationship between supply chain uncertainty and agility performance partially and significantly. Limitations: This research was limited to the Malaysian companies only whereas only limited dimensions of uncertainties and integration in the context of the supply chain were considered.