Fatigue, which is the common issue of every single worker in any area, tends to be worse in the service industry, especially in 24/7 continuous service like aviation, rail or medical. Comparing to all industries, shift work is a different element of service. For example, labor in aviation field like air traffic controller, cabin crew and ground staff mentioned shift work as a common cause of their fatigue beside specific job’s traits. The consequences of fatigue are low productivity, poor health and even high turnover rate which should be paid more attention by human resources management as an important task. In this case, imbalance shift distribution is the main cause of increasing fatigued level. Obviously, shift arrangement would not only decide how effective and appropriate shift system is, but also play a key role in fatigue level of workers.